Journal article icon

Journal article

Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg.

Abstract:

2-hydroxycarbazole, a compound structurally related to the Ca2+-mobilizing marine toxin 9-methyl-7-bromoeudistomin, has recently been proposed to activate both type 1 and type 2 ryanodine receptors in skeletal and cardiac muscle, respectively. This study was undertaken to evaluate the activity of this compound in the sea urchin egg homogenate, a model system used to characterize intracellular Ca2+ mobilization mechanisms. 2-Hydroxycarbazole was found to potently release Ca2+ in a concentratio...

Expand abstract
Publication status:
Published

Actions


Authors


Thomas, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
The Journal of pharmacology and experimental therapeutics
Volume:
298
Issue:
2
Pages:
644-650
Publication date:
2001-08-05
EISSN:
1521-0103
ISSN:
0022-3565
URN:
uuid:afcf3730-eb31-47f0-a2b1-3052c96e8b0f
Source identifiers:
106474
Local pid:
pubs:106474

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP