Distinct pharmacology of 2-hydroxycarbazole-induced Ca2+ release in the sea urchin egg.

Journal article

2-hydroxycarbazole, a compound structurally related to the Ca2+-mobilizing marine toxin 9-methyl-7-bromoeudistomin, has recently been proposed to activate both type 1 and type 2 ryanodine receptors in skeletal and cardiac muscle, respectively. This study was undertaken to evaluate the activity of this compound in the sea urchin egg homogenate, a model system used to characterize intracellular Ca2+ mobilization mechanisms. 2-Hydroxycarbazole was found to potently release Ca2+ in a concentratio...

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Authors: Thomas, J; Churchill, G; Patel, S; Galione, A

• Publication status: Published
• Journal: Journal of pharmacology and experimental therapeutics
• Volume: 298
• Issue: 2
• Pages: 644-650
• Publication date: 2001-08-01
• EISSN: 1521-0103
• ISSN: 0022-3565
• Language: English
• Keywords: Phosphodiesterase Inhibitors; Sea Urchins; Animals; Ovum; Calcium; Adenosine Diphosphate; Thapsigargin; Ryanodine Receptor Calcium Release Channel; Caffeine; Inositol 1,4,5-Trisphosphate; NADP; Enzyme Inhibitors; Carbazoles