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Polymorphisms at the Microseminoprotein-beta locus associated with physiologic variation in beta-microseminoprotein and prostate-specific antigen levels.

Abstract:

BACKGROUND: rs10993994, a single nucleotide polymorphism (SNP) at the genetic locus encoding beta-microseminoprotein (beta-MSP), is associated with both prostate cancer risk and levels of blood prostate-specific antigen (PSA), a biomarker used in prostate cancer screening. Therefore, we wished to determine the association between SNPs at MSMB, the gene encoding beta-MSP, and the levels of prostate-produced biomarkers beta-MSP, PSA, and human kallikrein 2 (hK2) in blood and semen. METHODS: Blo...

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Authors


Valtonen-André, C More by this author
Sävblom, C More by this author
Halldén, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
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Journal:
Cancer epidemiology, biomarkers and prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume:
19
Issue:
8
Pages:
2035-2042
Publication date:
2010-08-05
DOI:
EISSN:
1538-7755
ISSN:
1055-9965
URN:
uuid:afca09e1-0580-41c7-a142-9f82758aeba1
Source identifiers:
365896
Local pid:
pubs:365896

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