Journal article icon

Journal article

The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress

Abstract:

Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk and provide effective treatment options for many cancers. Here, we repurpose atovaquone (ATQ), a well-tolerated & FDA-approved anti-malarial agent by demonstrating that it potentiates cancer cell death of a subset of platinums. We show that ATQ in combination with carboplatin or cisplatin induces striking and repeatable concentration- a...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41420-020-00343-6

Authors


More by this author
Institution:
University of Oxford
Oxford college:
St Edmund Hall
Role:
Author
ORCID:
0000-0002-3286-3092
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
ORCID:
0000-0001-5196-0552
Publisher:
Springer Nature Publisher's website
Journal:
Cell Death Discovery Journal website
Volume:
6
Article number:
110
Publication date:
2020-10-27
Acceptance date:
2020-10-07
DOI:
EISSN:
2058-7716
Language:
English
Keywords:
Subjects:
Pubs id:
1137338
Local pid:
pubs:1137338
Deposit date:
2020-10-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP