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Monitoring homologous recombination following replication fork perturbation in the fission yeast Schizosaccharomyces pombe.

Abstract:

Replication forks (RFs) frequently encounter barriers or lesions in template DNA that can cause them to stall and/or break. Efficient genome duplication therefore depends on multiple mechanisms that variously act to stabilize, repair, and restart perturbed RFs. Integral to at least some of these mechanisms are homologous recombination (HR) proteins, but our knowledge of how they act to ensure high-fidelity genome replication remains incomplete. To help better understand the relationship betwe...

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
521
Pages:
535-552
Publication date:
2009-01-01
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:afba3cab-0f61-47ce-9485-31937f44cc4b
Source identifiers:
100367
Local pid:
pubs:100367

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