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Antigenic relationships among human pathogenic Orientia tsutsugamushi isolates from Thailand

Abstract:

Scrub typhus is a common cause of undiagnosed febrile illness in certain tropical regions, but can be easily treated with antibiotics. The causative agent, Orientia tsutsugamushi, is antigenically variable which complicates diagnosis and efforts towards vaccine development.This study aimed to dissect the antigenic and genetic relatedness of O. tsutsugamushi strains and investigate sero-diagnostic reactivities by titrating individual patient sera against their O. tsutsugamushi isolates (whole-...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pntd.0004723

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Nawtaisong, P More by this author
Tanganuchitcharnchai, A More by this author
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Wellcome Trust More from this funder
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Grant:
FP7 program ANTIGONE (278976)
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Neglected Tropical Diseases Journal website
Volume:
10
Issue:
6
Pages:
Article: e0004723
Publication date:
2016
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
URN:
uuid:afb3d90b-cae6-4ee6-9084-53b009747479
Source identifiers:
625182
Local pid:
pubs:625182
Language:
English

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