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Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.

Abstract:

Targeting of MHC class II molecules to the endocytic compartment where they encounter processed antigen is determined by the invariant chain (Ii). By analysis of Ii-transferrin receptor (TR) chimera trafficking, we have identified sorting signals in the Ii cytoplasmic tail and transmembrane region that mediate this process. Two non-tyrosine-based sorting signals in the Ii cytoplasmic tail were identified that mediate localization to plasma membrane clathrin-coated pits and promote rapid endoc...

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Publisher copy:
10.1083/jcb.126.2.317

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
The Journal of cell biology
Volume:
126
Issue:
2
Pages:
317-330
Publication date:
1994-07-05
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
URN:
uuid:afb25506-eb73-4c6f-8c8b-c4c5b8df1d5f
Source identifiers:
111211
Local pid:
pubs:111211

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