- Abstract:
-
Targeting of MHC class II molecules to the endocytic compartment where they encounter processed antigen is determined by the invariant chain (Ii). By analysis of Ii-transferrin receptor (TR) chimera trafficking, we have identified sorting signals in the Ii cytoplasmic tail and transmembrane region that mediate this process. Two non-tyrosine-based sorting signals in the Ii cytoplasmic tail were identified that mediate localization to plasma membrane clathrin-coated pits and promote rapid endoc...
Expand abstract - Publisher copy:
- 10.1083/jcb.126.2.317
-
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- Journal:
- The Journal of cell biology
- Volume:
- 126
- Issue:
- 2
- Pages:
- 317-330
- Publication date:
- 1994-07-05
- DOI:
- EISSN:
-
1540-8140
- ISSN:
-
0021-9525
- URN:
-
uuid:afb25506-eb73-4c6f-8c8b-c4c5b8df1d5f
- Source identifiers:
-
111211
- Local pid:
- pubs:111211
- Language:
- English
- Keywords:
- Copyright date:
- 1994
Journal article
Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.
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