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Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine

Abstract:

Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol adm...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.4049/jimmunol.1800142

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
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Role:
Author
ORCID:
0000-0002-0760-4347
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Zoology
Role:
Author
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Role:
Author
ORCID:
0000-0002-5315-3882
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Bill and Melinda Gates Foundation More from this funder
Townsend-Jeantet Prize Charitable Trust More from this funder
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
200
Issue:
12
Pages:
4068-4077
Publication date:
2018-06-04
Acceptance date:
2018-04-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:846169
URN:
uri:afadabf3-fe4e-496f-ace8-1760334deef8
UUID:
uuid:afadabf3-fe4e-496f-ace8-1760334deef8
Local pid:
pubs:846169
Language:
English
Keywords:

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