- Abstract:
-
Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol adm...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Publisher copy:
- 10.4049/jimmunol.1800142
-
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- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 200
- Issue:
- 12
- Pages:
- 4068-4077
- Publication date:
- 2018-06-04
- Acceptance date:
- 2018-04-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Pubs id:
-
pubs:846169
- URN:
-
uri:afadabf3-fe4e-496f-ace8-1760334deef8
- UUID:
-
uuid:afadabf3-fe4e-496f-ace8-1760334deef8
- Local pid:
- pubs:846169
- Language:
- English
- Keywords:
- Copyright holder:
- Holzer et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors. This article is distributed under the terms of the CC BY 4.0 Unported license.
Journal article
Comparison of heterosubtypic protection in ferrets and pigs induced by a single-cycle influenza vaccine
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Bill and Melinda Gates Foundation
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Townsend-Jeantet Prize Charitable Trust
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