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Inhibition of lysosomal Ca2+ signalling disrupts dendritic spine structure and impairs wound healing in neurons

Abstract:

A growing body of evidence suggests that lysosomes, which have traditionally been regarded as degradative organelles, can function as Ca2+ stores, regulated by the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP). We previously demonstrated that in hippocampal pyramidal neurons, activity-dependent Ca2+ release from these stores triggers fusion of the lysosome with the plasma membrane. We found that the physiological role of this Ca2+-depe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/19420889.2017.1344802

Authors


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Institution:
University of Oxford
Department:
Oxford, Magdalen College
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Funding agency for:
Padamsey, Z
Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Publisher:
Taylor and Francis Open Publisher's website
Journal:
Communicative and Integrative Biology Journal website
Volume:
10
Issue:
5-6
Pages:
Article: e1344802
Publication date:
2017-11-03
Acceptance date:
2017-06-15
DOI:
EISSN:
1942-0889
ISSN:
1942-0889
Pubs id:
pubs:700967
URN:
uri:af95e3bf-6ade-4739-a48d-3fde4e64a00a
UUID:
uuid:af95e3bf-6ade-4739-a48d-3fde4e64a00a
Local pid:
pubs:700967

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