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Journal article

Malaria parasite clearance

Abstract:

Following anti-malarial drug treatment asexual malaria parasite killing and clearance appear to be first order processes. Damaged malaria parasites in circulating erythrocytes are removed from the circulation mainly by the spleen. Splenic clearance functions increase markedly in acute malaria. Either the entire infected erythrocytes are removed because of their reduced deformability or increased antibody binding or, for the artemisinins which act on young ring stage parasites, splenic pitting...

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Publication status:
Published
Peer review status:
Reviewed (Other)
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-017-1731-1

Authors


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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
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Funding agency for:
White, N
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
16
Issue:
1
Pages:
Article: 88
Publication date:
2017-02-05
Acceptance date:
2017-02-08
DOI:
ISSN:
1475-2875
Pubs id:
pubs:678927
URN:
uri:af83f768-7199-4572-84f6-b7f77cb6f7ee
UUID:
uuid:af83f768-7199-4572-84f6-b7f77cb6f7ee
Local pid:
pubs:678927
Paper number:
1

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