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Journal article

NF-κB immunity in the brain determines fly lifespan in healthy aging and age-related neurodegeneration.

Abstract:

During aging, innate immunity progresses to a chronically active state. However, what distinguishes those that "age well" from those developing age-related neurological conditions is unclear. We used Drosophila to explore the cost of immunity in the aging brain. We show that mutations in intracellular negative regulators of the IMD/NF-κB pathway predisposed flies to toxic levels of antimicrobial peptides, resulting in early locomotor defects, extensive neurodegeneration, and reduced lifespan....

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.04.007

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Department:
Oxford, MSD, Biochemistry
Chtarbanova, S More by this author
Jayanth, D More by this author
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
19
Issue:
4
Pages:
836-848
Publication date:
2017-04-05
Acceptance date:
2017-03-31
DOI:
ISSN:
2211-1247
Pubs id:
pubs:692329
URN:
uri:af7fca15-8465-4f9a-9a3c-2ce03dba06bf
UUID:
uuid:af7fca15-8465-4f9a-9a3c-2ce03dba06bf
Local pid:
pubs:692329
Language:
English
Keywords:

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