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Journal article

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists.

Abstract:

Full activation of naive T cells requires both engagement of the T cell antigen receptor (TCR; signal 1) and costimulatory signaling by CD28 (signal 2). We previously identified two types of rat CD28-specific monoclonal antibodies (mAbs): "conventional," TCR signaling-dependent costimulatory mAbs and "superagonistic" mAbs capable of inducing the full activation of primary resting T cells in the absence of TCR ligation both in vitro and in vivo. Using chimeric rat/mouse CD28 molecules, we show...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20021024

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Journal:
The Journal of experimental medicine
Volume:
197
Issue:
8
Pages:
955-966
Publication date:
2003-04-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:af60fb90-4226-45f3-8408-c4121d95a58d
Source identifiers:
6011
Local pid:
pubs:6011

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