- Abstract:
-
Many haematological malignancies are associated with widespread alterations of the transcriptional and epigenetic programmes. Changes in DNA methylation provide the clearest example of epigenetic changes, but the mechanism(s) underlying such changes is unknown. To investigate this I studied DNA methylation across an ~80kb segment of the genome which is not known to be mutated in haematological malignancies. Methylation was perturbed in 35-100% of samples of DNA from individuals with a wide...
Expand abstract - Role:
- Supervisor
- Role:
- Supervisor
- Institution:
- University of Oxford
- Research group:
- Molecular Haematology Unit
- Oxford college:
- St John's College
- Department:
- Medical Sciences Division - Clinical Medicine,Nuffield Department of
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:af6091aa-3d00-4436-b2b7-5dfe439b5c05
- Local pid:
- ora:6440
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Noemi Roy
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available via ORA.
Thesis
The study of DNA methylation anomalies in chronic lymphocytic leukaemia
Actions
Authors
Contributors
+ Doug Higgs
+ Richard Gibbons
+ Noémi BA Roy
Funding
Bibliographic Details
Item Description
Terms of use
Metrics
Altmetrics
Dimensions
If you are the owner of this record, you can report an update to it here: Report update to this record