Thesis
The study of DNA methylation anomalies in chronic lymphocytic leukaemia
- Abstract:
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Many haematological malignancies are associated with widespread alterations of the transcriptional and epigenetic programmes. Changes in DNA methylation provide the clearest example of epigenetic changes, but the mechanism(s) underlying such changes is unknown. To investigate this I studied DNA methylation across an ~80kb segment of the genome which is not known to be mutated in haematological malignancies. Methylation was perturbed in 35-100% of samples of DNA from individuals with a wide...
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Authors
Contributors
+ Higgs, D
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Gibbons, R
Division:
MSD
Department:
NDM
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:af6091aa-3d00-4436-b2b7-5dfe439b5c05
- Local pid:
- ora:6440
- Deposit date:
- 2012-08-15
Terms of use
- Copyright holder:
- Noemi Roy
- Copyright date:
- 2012
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