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The study of DNA methylation anomalies in chronic lymphocytic leukaemia

Abstract:

Many haematological malignancies are associated with widespread alterations of the transcriptional and epigenetic programmes. Changes in DNA methylation provide the clearest example of epigenetic changes, but the mechanism(s) underlying such changes is unknown. To investigate this I studied DNA methylation across an ~80kb segment of the genome which is not known to be mutated in haematological malignancies. Methylation was perturbed in 35-100% of samples of DNA from individuals with a wide...

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Contributors

Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Molecular Haematology Unit
Oxford college:
St John's College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
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Funding agency for:
Noémi BA Roy
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:af6091aa-3d00-4436-b2b7-5dfe439b5c05
Local pid:
ora:6440

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