Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection.

Journal article

Apical membrane Ag 1 (AMA1) is one of the leading candidate Ags for inclusion in a subunit vaccine against blood-stage malaria. However, the efficacy of Ab-inducing recombinant AMA1 protein vaccines in phase IIa/b clinical trials remains disappointing. In this article, we describe the development of recombinant human adenovirus serotype 5 and modified vaccinia virus Ankara vectors encoding AMA1 from the Plasmodium chabaudi chabaudi strain AS. These vectors, when used in a heterologous prime-b...

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Authors: Biswas, S; Spencer, A; Forbes, E; Gilbert, S; Holder, A

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 188
• Issue: 10
• Pages: 5041-5053
• Publication date: 2012-05-01
• DOI: 10.4049/jimmunol.1101106
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Mice, Nude; Mice, Inbred BALB C; Molecular Sequence Data; Vaccines, Synthetic; Female; Vaccinia virus; Malaria Vaccines; Antigens, Protozoan; Malaria, Falciparum; Mice, Knockout; Antibodies, Protozoan; Antibodies, Viral; Adenoviruses, Human; Membrane Proteins; Plasmodium chabaudi; Plasmodium falciparum; Mice; Humans; Protozoan Proteins; Vaccines, Subunit; Genetic Vectors; Animals