- Abstract:
-
Tumor necrosis factor alpha (TNF alpha) is a cytokine with many biological functions of relevance to inflammatory disease. Although only one of several inflammatory mediators produced in abundance in rheumatoid arthritis (RA), experimental data suggest that it is in a dominant position within a cytokine hierarchy and is therefore a prime target for directed immunotherapy in this disease. We have targeted TNF alpha in vivo using a chimerised monoclonal anti-TNF alpha antibody and have now demo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0192-0561(94)00092-3
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- Journal:
- International journal of immunopharmacology
- Volume:
- 17
- Issue:
- 2
- Pages:
- 141-145
- Publication date:
- 1995-02-05
- DOI:
- ISSN:
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0192-0561
- URN:
-
uuid:af559445-ee83-4ead-86b5-c83396a26b18
- Source identifiers:
-
481647
- Local pid:
- pubs:481647
- Copyright date:
- 1995
Journal article
TNF alpha blockade in rheumatoid arthritis: rationale, clinical outcomes and mechanisms of action.
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