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Journal article

Quinine pharmacokinetics and toxicity in pregnant and lactating women with falciparum malaria.

Abstract:

Quinine dihydrochloride (10 mg or, in two patients, a loading dose of 20 mg kg-1) was infused intravenously over 4 h in ten severely ill but conscious women with falciparum malaria complicating the third trimester of pregnancy. Plasma quinine concentrations, measured spectrophotofluorimetrically after benzene extraction, fitted closely a single exponential decline after the intravenous infusion. These data were therefore fitted to a one compartment model: total apparent volume of distribution...

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Publication status:
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Journal:
British journal of clinical pharmacology
Volume:
21
Issue:
6
Pages:
677-683
Publication date:
1986-06-01
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
Source identifiers:
5381
Language:
English
Keywords:
Pubs id:
pubs:5381
UUID:
uuid:af50546c-5f39-434d-b914-f7426f385ffd
Local pid:
pubs:5381
Deposit date:
2012-12-19

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