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Quinine pharmacokinetics and toxicity in pregnant and lactating women with falciparum malaria.

Abstract:

Quinine dihydrochloride (10 mg or, in two patients, a loading dose of 20 mg kg-1) was infused intravenously over 4 h in ten severely ill but conscious women with falciparum malaria complicating the third trimester of pregnancy. Plasma quinine concentrations, measured spectrophotofluorimetrically after benzene extraction, fitted closely a single exponential decline after the intravenous infusion. These data were therefore fitted to a one compartment model: total apparent volume of distribution...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
British journal of clinical pharmacology
Volume:
21
Issue:
6
Pages:
677-683
Publication date:
1986-06-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:af50546c-5f39-434d-b914-f7426f385ffd
Source identifiers:
5381
Local pid:
pubs:5381

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