- Abstract:
-
Quinine dihydrochloride (10 mg or, in two patients, a loading dose of 20 mg kg-1) was infused intravenously over 4 h in ten severely ill but conscious women with falciparum malaria complicating the third trimester of pregnancy. Plasma quinine concentrations, measured spectrophotofluorimetrically after benzene extraction, fitted closely a single exponential decline after the intravenous infusion. These data were therefore fitted to a one compartment model: total apparent volume of distribution...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2125.1986.tb05233.x
-
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- Journal:
- British journal of clinical pharmacology
- Volume:
- 21
- Issue:
- 6
- Pages:
- 677-683
- Publication date:
- 1986-06-05
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- URN:
-
uuid:af50546c-5f39-434d-b914-f7426f385ffd
- Source identifiers:
-
5381
- Local pid:
- pubs:5381
- Copyright date:
- 1986
Journal article
Quinine pharmacokinetics and toxicity in pregnant and lactating women with falciparum malaria.
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