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Journal article

Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.

Abstract:

We evaluated the safety and immunogencity of a novel vaccine directed against autologous TNFalpha in a Phase I fixed dose escalation trial. The vaccine consisted of two recombinant TNFalpha proteins, with specific peptides replaced by foreign immunodominant T cell epitopes from tetanus toxoid. The main objectives were to establish a safe dose and evaluate the vaccines ability to raise neutralising TNFalpha antibodies. Secondary objectives were improvements in body weight and tumour response. ...

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Publication status:
Published

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Publisher copy:
10.1007/s00262-005-0661-x

Authors


Waterston, AM More by this author
Gumbrell, L More by this author
Gustav-Aspland, J More by this author
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Journal:
Cancer immunology, immunotherapy : CII
Volume:
54
Issue:
9
Pages:
848-857
Publication date:
2005-09-05
DOI:
EISSN:
1432-0851
ISSN:
0340-7004
URN:
uuid:af4cfea5-73c5-4729-9700-e9ceb850ce20
Source identifiers:
223902
Local pid:
pubs:223902

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