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Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Abstract:

Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (Pv), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (Pm). Correlations between Pv and Pm were stronger for SNPs with established marginal effe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1006812

Authors


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Funding agency for:
Morris, AP
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Funding agency for:
Franks, PW
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Funding agency for:
Franks, PW
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
13
Issue:
6
Pages:
Article: e1006812
Publication date:
2017-06-14
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:700946
URN:
uri:af4bbfe1-a2bf-4b33-a4b3-e1da8598c073
UUID:
uuid:af4bbfe1-a2bf-4b33-a4b3-e1da8598c073
Local pid:
pubs:700946
Paper number:
6
Language:
English

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