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Phorbol ester inhibits erythropoietin production in human hepatoma cells (Hep G2).

Abstract:

Using the human hepatoma cell line Hep G2, we have studied a possible role of protein kinase C (PKC) activity for regulation of erythropoietin (EPO) production. During a 72-h incubation, EPO production by the cells was stimulated sevenfold by exposure to low oxygen tension (1%) and threefold by exposure to cobaltous chloride (100 microM). The phorbol ester phorbol 12-myristate-13 acetate (PMA) led to a concentration-dependent inhibition of basal and stimulated EPO formation (ED50 10 nM). This...

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Publication status:
Published

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Journal:
The American journal of physiology
Volume:
262
Issue:
5 Pt 1
Pages:
C1204-C1210
Publication date:
1992-05-05
ISSN:
0002-9513
URN:
uuid:af4089b3-334c-45c0-94e4-d8f8ca2b0bc4
Source identifiers:
74057
Local pid:
pubs:74057

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