Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

Journal article

OBJECTIVES: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. METHODS: A meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations. Re...

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Authors: Evangelou, E; Valdes, A; Kerkhof, H; Styrkarsdottir, U; Zhu, Y

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 70
• Issue: 2
• Pages: 349-355
• Publication date: 2011-02-01
• DOI: 10.1136/ard.2010.132787
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Chromosomes, Human, Pair 7; Genotype; Gene Expression Profiling; Young Adult; Aged; Aged, 80 and over; Adult; Genetic Predisposition to Disease; Male; Female; Phenotype; Genome-Wide Association Study; Polymorphism, Single Nucleotide; arcOGEN Consortium; Middle Aged; Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA); Humans; Osteoarthritis, Knee