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Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD

Abstract:

Background

Infection-related exacerbations of respiratory diseases are a major health concern; thus understanding the mechanisms driving them is of paramount importance. Despite distinct inflammatory profiles and pathological differences, asthma and COPD share a common clinical facet: raised airway ATP levels. Furthermore, evidence is growing to suggest that infective agents can cause the release of extracellular vesicle (EVs) in vitro and in bodily fluids. ATP can evoke the P2X7/...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0101087

Authors


Raemdonck, KRG More by this author
Stevenson, CS More by this author
Snelgrove, RJ More by this author
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Contributors

Role:
Editor
Rosetree Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
9
Issue:
6
Pages:
e101087-e101087
Publication date:
2014-06-05
DOI:
EISSN:
1932-6203
URN:
uuid:af268e6f-107b-4975-a89e-5a8e8cc95a73
Source identifiers:
581370
Local pid:
pubs:581370

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