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A mathematical model of tumour and blood pHe regulation: The HCO3-/CO2 buffering system.

Abstract:

Malignant tumours are characterised by a low, acidic extracellular pH (pHe) which facilitates invasion and metastasis. Previous research has proposed the potential benefits of manipulating systemic pHe, and recent experiments have highlighted the potential for buffer therapy to raise tumour pHe, prevent metastases, and prolong survival in laboratory mice. To examine the physiological regulation of tumour buffering and investigate how perturbations of the buffering system (via metabolic/respir...

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Publication status:
Published

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Publisher copy:
10.1016/j.mbs.2010.12.002

Authors


Martin, NK More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Gatenby, RA More by this author
Gillies, RJ More by this author
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Journal:
Mathematical biosciences
Volume:
230
Issue:
1
Pages:
1-11
Publication date:
2011-03-05
DOI:
EISSN:
1879-3134
ISSN:
0025-5564
URN:
uuid:af1b1bea-6a3c-4cc4-83d5-0ddbeef16803
Source identifiers:
107055
Local pid:
pubs:107055

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