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Species-specific differences in the glucocorticoid receptor transactivation function upon binding with betamethasone-esters.

Abstract:

Glucocorticoids (GCs) are the most effective drugs for anti-inflammatory diseases. A number of adverse side effects, however, limit chronic treatment with GCs. To improve their therapeutic usefulness, attempts have been made to dissociate the two main actions of the glucocorticoid receptor (GR), transactivation and transrepression, which are believed to be responsible for the side effects and anti-inflammatory effects, respectively. We report here species-specific differences in the transacti...

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Publication status:
Published

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Authors


Tanigawa, K More by this author
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Journal:
International immunopharmacology
Volume:
2
Issue:
7
Pages:
941-950
Publication date:
2002-06-05
DOI:
EISSN:
1878-1705
ISSN:
1567-5769
URN:
uuid:af19d099-3008-4fc9-bcce-aef80835eb47
Source identifiers:
226989
Local pid:
pubs:226989

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