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Journal article

Intracellular proton mobility and buffering power in cardiac ventricular myocytes from rat, rabbit, and guinea pig.

Abstract:

Intracellular pH (pHi) is an important modulator of cardiac function. The spatial regulation of pH within the cytoplasm depends, in part, on intracellular H+ (Hi+) mobility. The apparent diffusion coefficient for Hi+, DHapp, was estimated in single ventricular myocytes isolated from the rat, guinea pig, and rabbit. DHapp was derived by best-fitting predictions of a two-dimensional model of H+ diffusion to the local rise of intracellular [H+], recorded confocally (ratiometric seminaphthorhodaf...

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Publication status:
Published

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Publisher copy:
10.1152/ajpheart.00277.2003

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
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Journal:
American journal of physiology. Heart and circulatory physiology
Volume:
285
Issue:
3
Pages:
H1236-H1246
Publication date:
2003-09-05
DOI:
EISSN:
1522-1539
ISSN:
0363-6135
URN:
uuid:af155ab9-a43b-4a1a-a4ab-7f455e40741f
Source identifiers:
106419
Local pid:
pubs:106419

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