Journal article
Model-based dynamic off-resonance correction for improved accelerated fMRI in awake behaving non-human primates
- Abstract:
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Purpose To estimate dynamic off-resonance due to vigorous body motion in accelerated fMRI of awake behaving non-human primates (NHPs) using the standard EPI 3-line navigator, in order to attenuate the effects of time-varying off-resonance on the reconstruction.
Methods In NHP fMRI the animal’s head is usually head-posted, and the dynamic off-resonance is mainly caused by motion in body parts that are distant from the brain and have low spatial frequency. Hence, off-resonance at each frame can be approximated as a spatially linear perturbation of the off-resonance at a reference frame, and is manifested as a relative linear shift in k-space. Using GRAPPA operators, we estimated these shifts by comparing the 3-line navigator at each time frame with that at the reference frame. Estimated shifts were then used to correct the data at each frame. The proposed method was evaluated in phantom scans, simulations, and in vivo data.
Results The proposed method is shown to successfully estimate low-spatial order dynamic off-resonance perturbations, including induced linear off-resonance perturbations in phantoms, and is able to correct retrospectively corrupted data in simulations. Finally, it is shown to reduce ghosting artifacts and geometric distortions by up to 20% in simultaneous multi-slice in vivo acquisitions in awake-behaving NHPs.
Conclusion A method is proposed that does not need any sequence modification or extra acquisitions and makes accelerated awake behaving NHP imaging more robust and reliable, reducing the gap between what is possible with NHP protocols and state-of-the-art human imaging.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1002/mrm.29167
Authors
- Publisher:
- Wiley
- Journal:
- Magnetic Resonance in Medicine More from this journal
- Volume:
- 87
- Issue:
- 6
- Pages:
- 2922-2932
- Publication date:
- 2022-01-26
- Acceptance date:
- 2022-01-03
- DOI:
- EISSN:
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1522-2594
- ISSN:
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0740-3194
- Language:
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English
- Keywords:
- Pubs id:
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1196614
- Local pid:
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pubs:1196614
- Deposit date:
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2022-01-07
Terms of use
- Copyright holder:
- Shahdloo et al.
- Copyright date:
- 2022
- Rights statement:
- ©2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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