- Abstract:
-
In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold is unclear. We show that scaffold assembly requires conserved Leucine Zipper (LZ) and Cnn-Motif 2 (CM2) domains that co-assemble into a 2:2 complex in vitro. We solve the crystal structure of the LZ:CM2 complex, revealing that both proteins form helical dimers that assemble into an unusual tetramer. A slightly longer version of the LZ c...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 5.4MB)
-
- Publisher copy:
- 10.1016/j.cell.2017.05.030
-
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- Funding agency for:
- Haensele, AFM
- Publisher:
- Elsevier (Cell Press) Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 169
- Issue:
- 6
- Pages:
- 1078–1089.e13
- Publication date:
- 2017-06-01
- Acceptance date:
- 2017-05-15
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Pubs id:
-
pubs:697002
- URN:
-
uri:aee04199-6bc2-4564-8b26-7241ed300419
- UUID:
-
uuid:aee04199-6bc2-4564-8b26-7241ed300419
- Local pid:
- pubs:697002
- Paper number:
- 6
- Keywords:
- Copyright holder:
- Feng et al.
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. Published by Elsevier Inc. Available under a Creative Commons Attribution (CC BY 4.0) Licence. Open access funded by the Wellcome Trust.
Journal article
Structural basis for mitotic centrosome assembly in flies
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+ Sir William Dunn School EPA PhD studentship
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