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Structural basis for mitotic centrosome assembly in flies

Abstract:

In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold is unclear. We show that scaffold assembly requires conserved Leucine Zipper (LZ) and Cnn-Motif 2 (CM2) domains that co-assemble into a 2:2 complex in vitro. We solve the crystal structure of the LZ:CM2 complex, revealing that both proteins form helical dimers that assemble into an unusual tetramer. A slightly longer version of the LZ c...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cell.2017.05.030

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Funding agency for:
Wainman, A
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Funding agency for:
Johnson, S
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Funding agency for:
Haensele, AFM
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Publisher:
Elsevier (Cell Press) Publisher's website
Journal:
Cell Journal website
Volume:
169
Issue:
6
Pages:
1078–1089.e13
Publication date:
2017-06-01
Acceptance date:
2017-05-15
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pubs id:
pubs:697002
URN:
uri:aee04199-6bc2-4564-8b26-7241ed300419
UUID:
uuid:aee04199-6bc2-4564-8b26-7241ed300419
Local pid:
pubs:697002
Paper number:
6

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