Journal article icon

Journal article

The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions

Abstract:

The biological consequences of clusters containing a single strand break and base lesion(s) remain largely unknown. In the present study we determined the mutagenicities of two- and three-lesion clustered damage sites containing a 1-nucleotide gap (GAP) and 8-oxo-7,8-dihydroguanine(s) (8-oxoG(s)) in . Escherichia coli. The mutation frequencies (MFs) of bi-stranded two-lesion clusters (GAP/8-oxoG), especially in . mutY-deficient strains, were high and were similar to those for bi-stranded clus...

Expand abstract

Actions


Access Document


Authors


Noguchi, M More by this author
Urushibara, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Shikazono, N More by this author
Journal:
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume:
732
Issue:
1-2
Pages:
34-42
Publication date:
2012-04-01
DOI:
EISSN:
0921-8262
ISSN:
0027-5107
URN:
uuid:aed63fc4-42dd-4682-8f46-719d48774434
Source identifiers:
322765
Local pid:
pubs:322765

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP