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Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells.

Abstract:

The association between HLA-B 2705 and the immune control of human immunodeficiency virus type 1 (HIV-1) has previously been linked to the targeting of the HLA-B 2705-restricted Gag epitope KRWIILGLNK (KK10) by CD8(+) T cells. In order to better define the mechanisms of the HLA-B 2705 immune control of HIV, we first characterized the CD8(+) T-cell responses of nine highly active antiretroviral therapy (HAART)-naïve B 2705-positive subjects. Unexpectedly, we observed a strong response to an HL...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00793-10

Authors


Kløverpris, H More by this author
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Journal:
Journal of virology
Volume:
84
Issue:
20
Pages:
10543-10557
Publication date:
2010-10-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:aed23446-2780-4ee7-9a7f-1b4af00d0e12
Source identifiers:
121085
Local pid:
pubs:121085

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