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Lessons learned from lung and liver in-vivo gene therapy: implications for the future

Abstract:
Introduction: Ex-vivo gene therapy has had significant clinical impact over the last couple of years and in-vivo gene therapy products are being approved for clinical use. Gene therapy and gene editing approaches have huge potential to treat genetic disease and chronic illness.

Areas covered: This article provides a review of in-vivo approaches for gene therapy in the lung and liver, exploiting non-viral and viral vectors with varying serotypes and... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1080/14712598.2018.1506761

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
ORCID:
0000-0002-8877-4005
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Sciences
Oxford college:
University College
ORCID:
0000-0002-5264-054X
More from this funder
Funding agency for:
Hyde, SC
More from this funder
Funding agency for:
Gill, DR
Publisher:
Taylor & Francis Publisher's website
Journal:
Expert Opinion on Biological Therapy Journal website
Volume:
18
Issue:
9
Pages:
959-972
Publication date:
2018-08-10
Acceptance date:
2018-07-27
DOI:
EISSN:
1744-7682
ISSN:
1471-2598
Pubs id:
pubs:894294
URN:
uri:aecc321b-34c3-4658-a0b9-7076512d9615
UUID:
uuid:aecc321b-34c3-4658-a0b9-7076512d9615
Local pid:
pubs:894294

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