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Journal article

AP2σ mutations impair calcium-sensing receptor trafficking and signaling, and reveal an endosomal pathway that spatially-directs G-protein selectivity

Abstract:

Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles of the endomembrane in regulating such pleiotropic signaling via multiple G-protein pathways remain unknown. Here, we investigated the effects of disease-causing mutations of the adaptor protein-2 σ subunit (AP2σ) on signaling by the class C GPCR ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.12.089

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Oxford college:
Exeter College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Role:
Author
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More from this funder
Funding agency for:
Rogers, A
More from this funder
Funding agency for:
Thakker, RV
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
22
Issue:
4
Pages:
1054-1066
Publication date:
2018-01-28
Acceptance date:
2017-12-22
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:823948
URN:
uri:aecb6eb1-003f-4a26-87ac-d862f04b21a7
UUID:
uuid:aecb6eb1-003f-4a26-87ac-d862f04b21a7
Local pid:
pubs:823948
Paper number:
4
Keywords:

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