Journal article
AP2σ mutations impair calcium-sensing receptor trafficking and signaling, and reveal an endosomal pathway that spatially-directs G-protein selectivity
- Abstract:
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Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles of the endomembrane in regulating such pleiotropic signaling via multiple G-protein pathways remain unknown. Here, we investigated the effects of disease-causing mutations of the adaptor protein-2 σ subunit (AP2σ) on signaling by the class C GPCR ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 4.3MB)
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- Publisher copy:
- 10.1016/j.celrep.2017.12.089
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Authors
Funding
+ Radcliffe Department of Medicine, University of Oxford
More from this funder
Funding agency for:
Gorvin, C
Grant:
G1000467
+ National Institute for Health Research
More from this funder
Funding agency for:
Thakker, R
Grant:
106995/z/15/z
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 22
- Issue:
- 4
- Pages:
- 1054-1066
- Publication date:
- 2018-01-28
- Acceptance date:
- 2017-12-22
- DOI:
- EISSN:
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2211-1247
- ISSN:
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2211-1247
- Source identifiers:
-
823948
Item Description
- Keywords:
- Pubs id:
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pubs:823948
- UUID:
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uuid:aecb6eb1-003f-4a26-87ac-d862f04b21a7
- Local pid:
- pubs:823948
- Deposit date:
- 2018-02-10
Terms of use
- Copyright holder:
- © 2017 Gorvin, et al
- Copyright date:
- 2018
- Notes:
- This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- Licence:
- CC Attribution (CC BY)
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