- Abstract:
-
Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles of the endomembrane in regulating such pleiotropic signaling via multiple G-protein pathways remain unknown. Here, we investigated the effects of disease-causing mutations of the adaptor protein-2 σ subunit (AP2σ) on signaling by the class C GPCR ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.3MB)
-
- Publisher copy:
- 10.1016/j.celrep.2017.12.089
-
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- Funding agency for:
- Gorvin, CM
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 22
- Issue:
- 4
- Pages:
- 1054-1066
- Publication date:
- 2018-01-28
- Acceptance date:
- 2017-12-22
- DOI:
- EISSN:
-
2211-1247
- ISSN:
-
2211-1247
- Pubs id:
-
pubs:823948
- URN:
-
uri:aecb6eb1-003f-4a26-87ac-d862f04b21a7
- UUID:
-
uuid:aecb6eb1-003f-4a26-87ac-d862f04b21a7
- Local pid:
- pubs:823948
- Paper number:
- 4
- Keywords:
- Copyright holder:
- © 2017 Gorvin, et al.
- Copyright date:
- 2018
- Notes:
- This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Journal article
AP2σ mutations impair calcium-sensing receptor trafficking and signaling, and reveal an endosomal pathway that spatially-directs G-protein selectivity
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+ Radcliffe Department of Medicine, University of Oxford
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