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Histone deacetylase inhibitors enhance CD4 T cell susceptibility to NK cell killing but reduce NK cell function

Abstract:

In the search for a cure for HIV-1 infection, histone deacetylase inhibitors (HDACi) are being investigated as activators of latently infected CD4 T cells to promote their targeting by cytotoxic T-lymphocytes (CTL). However, HDACi may also inhibit CTL function, suggesting different immunotherapy approaches may need to be explored. Here, we study the impact of different HDACi on both Natural Killer (NK) and CTL targeting of HIV-1 infected cells. We found HDACi down-regulated HLA class I expres...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1005782

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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
Role:
Author
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Oxford Martin School More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
12
Issue:
8
Pages:
Article: e1005782
Publication date:
2016-01-01
Acceptance date:
2016-07-28
DOI:
ISSN:
1553-7374
Pubs id:
pubs:639155
URN:
uri:aecac648-2377-4dc2-8333-98eea9dc52e7
UUID:
aecac648-2377-4dc2-8333-98eea9dc52e7
Local pid:
pubs:639155
Paper number:
8

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