- Abstract:
-
In the search for a cure for HIV-1 infection, histone deacetylase inhibitors (HDACi) are being investigated as activators of latently infected CD4 T cells to promote their targeting by cytotoxic T-lymphocytes (CTL). However, HDACi may also inhibit CTL function, suggesting different immunotherapy approaches may need to be explored. Here, we study the impact of different HDACi on both Natural Killer (NK) and CTL targeting of HIV-1 infected cells. We found HDACi down-regulated HLA class I expres...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 4.8MB)
-
- Publisher copy:
- 10.1371/journal.ppat.1005782
-
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Pathogens Journal website
- Volume:
- 12
- Issue:
- 8
- Pages:
- Article: e1005782
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-07-28
- DOI:
- ISSN:
-
1553-7374
- Pubs id:
-
pubs:639155
- URN:
-
uri:aecac648-2377-4dc2-8333-98eea9dc52e7
- UUID:
-
aecac648-2377-4dc2-8333-98eea9dc52e7
- Local pid:
- pubs:639155
- Paper number:
- 8
- Copyright holder:
- Pace et al.
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Pace et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Histone deacetylase inhibitors enhance CD4 T cell susceptibility to NK cell killing but reduce NK cell function
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Funding
Oxford Martin School
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National Institute for Health Research Oxford Biomedical Research Centre
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Medical Research Council
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