Journal article icon

Journal article

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

Abstract:

The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively unexplored. Here we report that inhibition of vimentin using the steroidal lactone Withaferin A (WFA) causes vimentin to aggregate, and this is associated with the relocalisation of organelles including autophagosomes and lysosomes from the cytoso...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0209665

Authors


More by this author
Role:
Author
ORCID:
0000-0002-6239-5269
Publisher:
Public Library of Science Publisher's website
Journal:
PloS ONE Journal website
Volume:
14
Issue:
1
Article number:
e0209665
Publication date:
2019-01-30
Acceptance date:
2018-12-10
DOI:
ISSN:
1932-6203
Pmid:
30699149
Source identifiers:
969582
Language:
English
Pubs id:
pubs:969582
UUID:
uuid:aec49cec-a383-41e2-90d7-cad3dbd73063
Local pid:
pubs:969582
Deposit date:
2019-04-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP