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Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells.

Abstract:

Synthetic vectors were evaluated for their ability to mediate efficient mRNA transfection. Initial results indicated that lipoplexes, but not polyplexes based on polyethylenimine (PEI, 25 and 22 kDa), poly(L-lysine) (PLL, 54 kDa) or dendrimers, mediated efficient translation of mRNA in B16-F10 cells. Significant mRNA transfection was achieved by lipoplex delivery in quiescent (passage 0) human umbilical vein endothelial cells (HUVEC), and by passage 4, 10.7% of HUVEC were transfected compared...

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Publication status:
Published

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Publisher copy:
10.1093/nar/29.18.3882

Authors


Bettinger, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Seymour, LW More by this author
Journal:
Nucleic acids research
Volume:
29
Issue:
18
Pages:
3882-3891
Publication date:
2001-09-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:aec4706c-0281-4c4f-9b19-647e3290197c
Source identifiers:
397121
Local pid:
pubs:397121

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