Journal article icon

Journal article

Centrosome amplification can initiate tumorigenesis in flies.

Abstract:

Centrosome amplification is a common feature of many cancer cells, and it has been previously proposed that centrosome amplification can drive genetic instability and so tumorigenesis. To test this hypothesis, we generated Drosophila lines that have extra centrosomes in approximately 60% of their somatic cells. Many cells with extra centrosomes initially form multipolar spindles, but these spindles ultimately become bipolar. This requires a delay in mitosis that is mediated by the spindle ass...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.cell.2008.05.039

Authors


Vinadogrova, T More by this author
Expand authors...
Journal:
Cell
Volume:
133
Issue:
6
Pages:
1032-1042
Publication date:
2008-06-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:aeb6a455-9f11-4397-b1e4-1ecacd726eeb
Source identifiers:
223391
Local pid:
pubs:223391

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP