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Journal article

Evidence for a post-entry barrier to R5 HIV-1 infection of CD4 memory T cells.

Abstract:

BACKGROUND: HIV-1 strains R5 and X4 can infect CD4 memory T cells in vivo. Anti-CD3/28 stimulation induces beta-chemokines and CCR5 down-regulation and renders these cells resistant to R5 HIV-1 infection. Here we describe an additional cellular mechanism that blocks productive R5 HIV-1 infection of CD4 memory T cells. METHODS: Blood-derived CD4 memory T cells and CD4 T-cell clones were infected with primary R5 and X4 HIV-1 strains. Virus replication was correlated with CCR5 expression and bet...

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Publication status:
Published

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Authors


Vyakarnam, A More by this author
Zuckerman, M More by this author
Babaahmady, K More by this author
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Journal:
AIDS (London, England)
Volume:
15
Issue:
13
Pages:
1613-1626
Publication date:
2001-09-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:ae966748-2c14-44e3-8b36-15cd024d4c04
Source identifiers:
176592
Local pid:
pubs:176592

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