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Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: Converging results from multimodal magnetic resonance imaging

Abstract:

The neural substrate underlying cognitive impairments after chemotherapy is largely unknown. Here, we investigated very late (>9 years) effects of adjuvant high-dose chemotherapy on brain white and gray matter in primary breast cancer survivors (n = 17) with multimodal magnetic resonance imaging (MRI). A group of breast cancer survivors who did not receive chemotherapy was scanned for comparison (n = 15). Neuropsychological tests demonstrated cognitive impairments in the chemotherapy group...

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Publisher copy:
10.1002/hbm.21422

Authors


De Ruiter, MB More by this author
Reneman, L More by this author
Boogerd, W More by this author
Veltman, DJ More by this author
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Journal:
Human Brain Mapping
Volume:
33
Issue:
12
Pages:
2971-2983
Publication date:
2012-12-05
DOI:
EISSN:
1097-0193
ISSN:
1065-9471
URN:
uuid:ae84870e-0e2b-4725-82d0-4fa9624097f8
Source identifiers:
364470
Local pid:
pubs:364470

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