Cytokine production in culture by cells isolated from the synovial membrane.

Journal article

Cytokine expression was investigated in synovial cell cultures isolated from diseased joints of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by both RA and OA synovial cells. There was no correlation between cell composition and level of TNF alpha produced. In contrast, lymphotoxin (LT) and Interferon gamma (IFN gamma) (greater than 50 pg/ml) were not found. This was further investigated in ...

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Authors: Brennan, F; Chantry, D; Jackson, A; Maini, R; Feldmann, M

• Publication status: Published
• Journal: Journal of autoimmunity
• Volume: 2 Suppl
• Issue: SUPPL. 1
• Pages: 177-186
• Publication date: 1989-06-01
• DOI: 10.1016/0896-8411(89)90129-7
• EISSN: 1095-9157
• ISSN: 0896-8411
• Language: English
• Keywords: Cytokines; Synovial Membrane; Interleukin-1; Biological Factors; Humans; Gene Expression Regulation; Arthritis, Rheumatoid; Osteoarthritis; Tumor Necrosis Factor-alpha; Lymphotoxin-alpha; Interferon-gamma; Cells, Cultured; RNA, Messenger