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Cytokine production in culture by cells isolated from the synovial membrane.

Abstract:

Cytokine expression was investigated in synovial cell cultures isolated from diseased joints of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by both RA and OA synovial cells. There was no correlation between cell composition and level of TNF alpha produced. In contrast, lymphotoxin (LT) and Interferon gamma (IFN gamma) (greater than 50 pg/ml) were not found. This was further investigated in ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Journal:
Journal of autoimmunity
Volume:
2 Suppl
Issue:
SUPPL. 1
Pages:
177-186
Publication date:
1989-06-01
DOI:
EISSN:
1095-9157
ISSN:
0896-8411
Source identifiers:
481769
Language:
English
Keywords:
Pubs id:
pubs:481769
UUID:
uuid:ae79a2a3-8206-4538-b2c9-79fe35dad7f8
Local pid:
pubs:481769
Deposit date:
2014-08-29

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