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No glucotoxicity after 53 hours of 6.0 mmol/l hyperglycaemia in normal man.

Abstract:

In vitro and in vivo studies have suggested that metabolic deterioration can be induced by hyperglycaemia per se. The effect of 53 h of 2.2 mg glucose.kg ideal body weight-1.min-1 was examined in four normal male subjects. This produced overnight hyperglycaemia of 6.0 mmol/l on the two nights of the study compared with 4.7 mmol/l on the control night (p less than 0.05). In response there was a sustained, two-fold increase in basal plasma insulin (p less than 0.005) and C-peptide (p less than ...

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Publication status:
Published

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Publisher copy:
10.1007/bf00400275

Authors


Matthews, DR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Coppack, SW More by this author
Turner, RC More by this author
Journal:
Diabetologia
Volume:
34
Issue:
8
Pages:
570-575
Publication date:
1991-08-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:ae5a6066-c74f-4aa5-b980-1653bf072c8f
Source identifiers:
34681
Local pid:
pubs:34681

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