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alpha- and beta-secretase: profound changes in Alzheimer's disease.

Abstract:

The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of beta-amyloid (Abeta) peptide, which is cleaved from Amyloid Precursor Protein (APP) by the enzyme beta-secretase. Only small amounts of Abeta form in normal brain; more typically this is precluded by the processing of APP by alpha-secretase. Here, we describe a decrease in alpha-secretase (81% of normal) and a large increase in beta-secretase activity (185%) in sporadic Alzheimer's diseas...

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Publication status:
Published

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Authors


Dawbarn, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Biochemical and biophysical research communications
Volume:
299
Issue:
3
Pages:
373-376
Publication date:
2002-12-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:ae46ce0d-49cb-4d8d-ba34-59af848323c3
Source identifiers:
32255
Local pid:
pubs:32255

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