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Journal article

Exome-wide association study of plasma lipids in >300,000 individuals.

Abstract:

We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ng.3977

Authors


Peloso, GM More by this author
Butterworth, AS More by this author
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Stanley J. Sarnoff Cardiovascular Research Foundation More from this funder
Japanese Circulation Society More from this funder
National Institute for Health Research More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Genetics Journal website
Volume:
49
Pages:
1758–1766
Publication date:
2017-10-30
Acceptance date:
2017-09-26
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:742114
URN:
uri:ae434285-544c-4b71-8418-ef2ff763c2df
UUID:
uuid:ae434285-544c-4b71-8418-ef2ff763c2df
Local pid:
pubs:742114

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