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5-Aminosalicylic acid inhibits the impaired epithelial barrier function induced by gamma interferon.

Abstract:

Gamma interferon (IFN gamma) impairs epithelial barrier function and induces HLA-DR expression on colonic cancer cell lines. Salicylates have been shown to reduce IFN gamma induced HLA-DR expression. The effect of 5-aminosalicylic acid (5-ASA) on IFN gamma induced changes in transepithelial resistance and permeability was investigated in HT29 clone 19A and Caco 2 monolayers. Monolayers were incubated with different concentrations of IFN gamma (100, 500, 1000, and 3000 U/ml) and 5-ASA. IFN gam...

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Publication status:
Published

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Publisher copy:
10.1136/gut.38.1.115

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Gut More from this journal
Volume:
38
Issue:
1
Pages:
115-119
Publication date:
1996-01-01
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
Language:
English
Keywords:
Pubs id:
pubs:135429
UUID:
uuid:ae4035bb-91e8-49ee-911a-a04d2b9b43e0
Local pid:
pubs:135429
Source identifiers:
135429
Deposit date:
2012-12-19

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