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Journal article

Viral infection and iron metabolism.

Abstract:

Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron-replete host. Some viruses selectively infect iron-acquiring cells by binding to transferrin receptor 1 during cell entry. Other viruses alter the expression of proteins involved in iron homeostasis, such as HFE and hepcidin. In HIV-1 and hepatitis C virus infections, iron overload is associated with poor prognosi...

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Publication status:
Published

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Publisher copy:
10.1038/nrmicro1930

Authors


Journal:
Nature reviews. Microbiology
Volume:
6
Issue:
7
Pages:
541-552
Publication date:
2008-07-05
DOI:
EISSN:
1740-1534
ISSN:
1740-1526
URN:
uuid:ae3dade1-83fe-4a9b-b87f-59a1eafc26d5
Source identifiers:
49990
Local pid:
pubs:49990

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