Journal article
Viral infection and iron metabolism.
- Abstract:
-
Fundamental cellular operations, including DNA synthesis and the generation of ATP, require iron. Viruses hijack cells in order to replicate, and efficient replication needs an iron-replete host. Some viruses selectively infect iron-acquiring cells by binding to transferrin receptor 1 during cell entry. Other viruses alter the expression of proteins involved in iron homeostasis, such as HFE and hepcidin. In HIV-1 and hepatitis C virus infections, iron overload is associated with poor prognosi...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nrmicro1930
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Authors
Bibliographic Details
- Journal:
- Nature reviews. Microbiology
- Volume:
- 6
- Issue:
- 7
- Pages:
- 541-552
- Publication date:
- 2008-07-01
- DOI:
- EISSN:
-
1740-1534
- ISSN:
-
1740-1526
- Source identifiers:
-
49990
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:49990
- UUID:
-
uuid:ae3dade1-83fe-4a9b-b87f-59a1eafc26d5
- Local pid:
- pubs:49990
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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