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A chromomeric model for nuclear and chromosome structure.

Abstract:

The basic structural elements of chromatin and chromosomes are reviewed. Then a model involving only three architectural motifs, nucleosomes, chromatin loops and transcription factories/chromomeres, is presented. Loops are tied through transcription factors and RNA polymerases to factories during interphase and to the remnants of those factories, chromomeres, during mitosis. On entry into mitosis, increased adhesiveness between nucleosomes and between factories drives a 'sticky-end' aggregati...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
108 ( Pt 9)
Pages:
2927-2935
Publication date:
1995-09-01
EISSN:
1477-9137
ISSN:
0021-9533
Source identifiers:
28614
Language:
English
Keywords:
Pubs id:
pubs:28614
UUID:
uuid:ae36304e-595c-4998-b1d1-2c1bb8137f84
Local pid:
pubs:28614
Deposit date:
2012-12-19

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