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Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.

Abstract:

BACKGROUND: We have recently shown that the severity of human colonic familial adenomatous polyposis (FAP) varies in a manner consistent with the action of modifier genes. These modifier genes may harbour common alleles which increase the risk of colorectal cancer (CRC) in the general population. Analyses have suggested several common polymorphisms as risk alleles for CRC. METHODS: We determined the association between the severity of colonic FAP (151 patients) and polymorphisms in MTHFR, NA...

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Publisher copy:
10.1136/gut.2003.015586

Authors


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Journal:
Gut
Volume:
53
Issue:
2
Pages:
271-276
Publication date:
2004-02-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:ae2db264-67e0-4ba8-a5a2-2152e2cb4e24
Source identifiers:
72223
Local pid:
pubs:72223

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