Journal article icon

Journal article

Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases

Abstract:

Multi-subunit Cullin-RING E3 ligases often use repeat domain proteins as substrate-specific adaptors. Structures of these macromolecular assemblies are determined for the F-box-containing leucine-rich repeat and WD40 repeat families, but not for the suppressor of cytokine signaling (SOCS)-box-containing ankyrin repeat proteins (ASB1-18), which assemble with Elongins B and C and Cul5. We determined the crystal structures of the ternary complex of ASB9-Elongin B/C as well as the interacting N-t...

Expand abstract

Actions


Access Document


Publisher copy:
10.1016/j.jmb.2013.06.015

Authors


Muniz, JRC More by this author
Kershaw, NJ More by this author
Ayinampudi, V More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Expand authors...
Journal:
Journal of Molecular Biology
Volume:
425
Issue:
17
Pages:
3166-3177
Publication date:
2013-09-09
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:ae2b6783-c4b9-4240-95e1-1955b325f1cd
Source identifiers:
419300
Local pid:
pubs:419300

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP