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Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis

Abstract:

HIV-1 and HIV-2 share many similarities including their basic gene arrangement, modes of transmission, intracellular replication pathways and clinical consequences: both result in AIDS. However, HIV-2 is characterised by lower transmissibility and reduced likelihood of progression to AIDS. The underlying mechanistic differences between these two infections illuminate broader issues of retroviral pathogenesis, which remain incompletely understood. Comparisons between these two infections from ...

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Publisher copy:
10.1002/rmv.1739

Authors


Nyamweya, S More by this author
Hegedus, A More by this author
Rowland-Jones, S More by this author
Flanagan, KL More by this author
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Journal:
Reviews in Medical Virology
Volume:
23
Issue:
4
Pages:
221-240
Publication date:
2013-07-05
DOI:
EISSN:
1099-1654
ISSN:
1052-9276
URN:
uuid:ae221182-80a1-4e2d-afdc-5317d10cbc05
Source identifiers:
411832
Local pid:
pubs:411832
Language:
English

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