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Journal article

Dual role of CDKs in DNA repair: to be, or not to be.

Abstract:

The maintenance of genome integrity is essential for the regulation of cell proliferation and differentiation. DNA must be accurately duplicated and segregated to daughter cells at cell division, a process that is primarily regulated by cyclin-dependent kinases (CDKs). During cell growth, however, it is inevitable that DNA breaks will occur due to endogenous and exogenous stresses. Interestingly, there is increasing evidence that the catalytic activities of CDKs play critical roles in the DNA...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
DNA repair
Volume:
8
Issue:
1
Pages:
6-18
Publication date:
2009-01-05
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
URN:
uuid:ae14de76-fe8e-43a5-b9ae-c02d9c1e1422
Source identifiers:
55362
Local pid:
pubs:55362

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