FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.

Journal article

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradoxically restricted to acute myeloid leukemia even though Flt3 primarily promotes lymphoid development during normal hematopoiesis. When expressed in MPPs, Flt3-ITD collaborated with Runx1 mutation to induce high-penetrance aggressive leukemias that...

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Authors: Mead, A; Kharazi, S; Atkinson, D; Macaulay, I; Pecquet, C

• Publication status: Published
• Journal: Cell reports
• Volume: 3
• Issue: 6
• Pages: 1766-1776
• Publication date: 2013-06-01
• DOI: 10.1016/j.celrep.2013.04.031
• EISSN: 2211-1247
• ISSN: 2211-1247
• Language: English
• Keywords: Microarray Analysis; fms-Like Tyrosine Kinase 3; Cell Differentiation; Multipotent Stem Cells; Animals; Signal Transduction; Gene Expression; Flow Cytometry; Mice; Disease Models, Animal; Myeloid Cells; Humans; Cell Transformation, Neoplastic; Leukemia, Myeloid, Acute