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The importance of context: uncovering species- and tissue-specific effects of genetic risk variants for type 2 diabetes

Abstract:

Genome-wide association studies (GWAS) have been highly successful in identifying genetic variation associated with type 2 diabetes (T2D) risk and related quantitative traits (1–3). The vast majority of association signals are located in non-coding regions of the genome, influencing nearby genes through regulation of transcriptional, translational, or splicing activity (4). Due to the highly context-dependent nature of gene expression, the effects of many risk variants are restricted to speci...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fendo.2016.00112

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Department:
Oxford, MSD, RDM, OCDEM
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Department:
Oxford, MSD, RDM, RDM Strategic
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Department:
Oxford, MSD, RDM, OCDEM
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Funding agency for:
McCarthy, M
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Funding agency for:
Gloyn, AL
Publisher:
Frontiers Publisher's website
Journal:
Frontiers in Endocrinology Journal website
Volume:
7
Pages:
Article 112
Publication date:
2016
Acceptance date:
2016-08-04
DOI:
ISSN:
1664-2392
Pubs id:
pubs:642662
URN:
uri:ae0d8d74-89c1-453e-a8fd-5c5252946a9b
UUID:
uuid:ae0d8d74-89c1-453e-a8fd-5c5252946a9b
Local pid:
pubs:642662

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