Journal article
The importance of context: uncovering species- and tissue-specific effects of genetic risk variants for type 2 diabetes
- Abstract:
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Genome-wide association studies (GWAS) have been highly successful in identifying genetic variation associated with type 2 diabetes (T2D) risk and related quantitative traits (1–3). The vast majority of association signals are located in non-coding regions of the genome, influencing nearby genes through regulation of transcriptional, translational, or splicing activity (4). Due to the highly context-dependent nature of gene expression, the effects of many risk variants are restricted to speci...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 528.0KB, Terms of use)
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- Publisher copy:
- 10.3389/fendo.2016.00112
Authors
Funding
+ Wellcome Trust
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Funding agency for:
McCarthy, M
Gloyn, A
Grant:
Senior Investigator
Senior fellow in Basic Biomedical Science (095101)
Bibliographic Details
- Publisher:
- Frontiers
- Journal:
- Frontiers in Endocrinology More from this journal
- Volume:
- 7
- Pages:
- Article 112
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-08-04
- DOI:
- ISSN:
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1664-2392
Item Description
- Keywords:
- Pubs id:
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pubs:642662
- UUID:
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uuid:ae0d8d74-89c1-453e-a8fd-5c5252946a9b
- Local pid:
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pubs:642662
- Source identifiers:
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642662
- Deposit date:
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2016-09-13
Terms of use
- Copyright holder:
- Thomsen et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 Thomsen, McCarthy and Gloyn. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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