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Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.

Abstract:

Genome-wide association studies (GWAS) have identified multiple single nucleotide polymorphisms (SNPs) associated with prostate cancer risk. However, whether these associations can be consistently replicated, vary with disease aggressiveness (tumor stage and grade) and/or interact with non-genetic potential risk factors or other SNPs is unknown. We therefore genotyped 39 SNPs from regions identified by several prostate cancer GWAS in 10,501 prostate cancer cases and 10,831 controls from the N...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0017142

Authors


Lindstrom, S More by this author
Schumacher, F More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit
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Journal:
PloS one
Volume:
6
Issue:
2
Pages:
e17142
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:ae081079-7499-4815-b1d1-373b77f14433
Source identifiers:
124553
Local pid:
pubs:124553

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