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Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease.

Abstract:

Serotonin1A receptor density and serotonin concentration were measured in the postmortem neocortex of 17 AD patients who had been prospectively assessed every four months with the Mini-Mental State Examination (MMSE) for a mean of 2.6 years till death. In the frontal cortex, serotonin levels correlated negatively with the annual rate of MMSE decline, while serotonin1A receptor density was positively correlated with the rate of MMSE decline. Our study suggests that reduced serotonin levels and...

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Publication status:
Published

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Journal:
Neuroreport
Volume:
13
Issue:
9
Pages:
1175-1178
Publication date:
2002-07-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:ae05ab6f-05a5-4731-97f7-b2f2431c8339
Source identifiers:
180243
Local pid:
pubs:180243

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